NtdR

• Description: transcription activator of the ntdA-ntdB-ntdC-glcP operon
  
  

Gene name	ntdR
Synonyms	yhjM
Essential	no
Product	transcriptional regulator (LacI family)
Function	regulation of the ntdA-ntdB-ntdC-glcP operon
Gene expression levels in SubtiExpress: ntdR
MW, pI	37 kDa, 6.645
Gene length, protein length	987 bp, 329 aa
Immediate neighbours	ntdA, yhjN
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

miscellaneous metabolic pathways, transcription factors and their control, biosynthesis of antibacterial compounds

This gene is a member of the following regulons

AbrB regulon

The NtdR regulon:

• ntdA-ntdB-ntdC-glcP

The gene

Basic information

• Locus tag: BSU10560

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: transcription activation of the ntdA-ntdB-ntdC-glcP operon PubMed

• Protein family: LacI family

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O07567

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ntdR PubMed

• Expression browser: ntdR PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:
  • AbrB: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Takashi Inaoka, Kozo Ochi
Activation of dormant secondary metabolism neotrehalosadiamine synthesis by an RNA polymerase mutation in Bacillus subtilis.
Biosci Biotechnol Biochem: 2011, 75(4);618-23
[PubMed:21512256] [WorldCat.org] [DOI] (I p)

Original publications

Additional publications: PubMed

Takashi Inaoka, Kozo Ochi
Glucose uptake pathway-specific regulation of synthesis of neotrehalosadiamine, a novel autoinducer produced in Bacillus subtilis.
J Bacteriol: 2007, 189(1);65-75
[PubMed:17056753] [WorldCat.org] [DOI] (P p)

Takashi Inaoka, Kosaku Takahashi, Hiroshi Yada, Mitsuru Yoshida, Kozo Ochi
RNA polymerase mutation activates the production of a dormant antibiotic 3,3'-neotrehalosadiamine via an autoinduction mechanism in Bacillus subtilis.
J Biol Chem: 2004, 279(5);3885-92
[PubMed:14612444] [WorldCat.org] [DOI] (P p)