ManA

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  • Description: mannose-6-phosphate isomerase, required for proper cell wall synthesis

Gene name manA
Synonyms yjdE
Essential no
Product mannose-6-phosphate isomerase
Function mannose utilization
Metabolic function and regulation of this protein in SubtiPathways:
Sugar catabolism
MW, pI 35 kDa, 5.279
Gene length, protein length 945 bp, 315 aa
Immediate neighbours manP, yjdF
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
ManA context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

utilization of specific carbon sources

This gene is a member of the following regulons

ManR regulon

The gene

Basic information

  • Locus tag: BSU12020

Phenotypes of a mutant

  • cells lose the characteristic rod shape typical of wild type B. subtilis cells and instead appear as elongated spheres, which are significantly larger than normal PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Regulatory mechanism:
    • ManR: transcription activation in the presence of mannose and absence of glucose PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References