YlbQ

• Description: 2-dehydropantoate 2-reductase
  
  

Gene name	ylbQ
Synonyms
Essential	no
Product	2-dehydropantoate 2-reductase
Function	biosynthesis of coenzyme A
MW, pI	33 kDa, 5.857
Gene length, protein length	894 bp, 298 aa
Immediate neighbours	ylbP, bshC
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

biosynthesis of cofactors

The gene

Basic information

• Locus tag: BSU15110

Expression

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: (R)-pantoate + NADP⁺ = 2-dehydropantoate + NADPH (according to Swiss-Prot)

• Protein family: ketopantoate reductase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure: 3LGO

• UniProt: O34661

• KEGG entry: [2]

• E.C. number: 1.1.1.169

Expression and regulation

• Operon: ylbQ-bshC PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Operon and expression

Ahmed Gaballa, Gerald L Newton, Haike Antelmann, Derek Parsonage, Heather Upton, Mamta Rawat, Al Claiborne, Robert C Fahey, John D Helmann
Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli.
Proc Natl Acad Sci U S A: 2010, 107(14);6482-6
[PubMed:20308541] [WorldCat.org] [DOI] (I p)