YpbH

• Description: putative adaptor protein
  
  

Gene name	ypbH
Synonyms
Essential	no
Product	putative adaptor protein
Function	unknown
MW, pI	22 kDa, 4.095
Gene length, protein length	582 bp, 194 aa
Immediate neighbours	gudB, ypbG
Gene sequence (+200bp)	Protein sequence
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

proteolysis

The gene

Basic information

• Locus tag: BSU22970

Phenotypes of a mutant

deletion reduces sporulation to 20%, overexpression abolishes sporulation PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s): MecA

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: YpbH-ClpC PubMed

• Localization:

Database entries

• Structure: 3JTO (C-terminal domain) PubMed

• UniProt: P50734

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:
  • low expression, enhanced in stat phase in LB or competence but not in sporulation medium PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant: GP812 (spc), GP814 (spc) both available in the Stülke lab

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Janine Kirstein, Noël Molière, David A Dougan, Kürşad Turgay
Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases.
Nat Rev Microbiol: 2009, 7(8);589-99
[PubMed:19609260] [WorldCat.org] [DOI] (I p)

Original Publications

Feng Wang, Ziqing Mei, Yutao Qi, Chuangye Yan, Siheng Xiang, Zhiyuan Zhou, Qi Hu, Jiawei Wang, Yigong Shi
Crystal structure of the MecA degradation tag.
J Biol Chem: 2009, 284(49);34376-81
[PubMed:19801546] [WorldCat.org] [DOI] (I p)

Marjan Persuh, Ines Mandic-Mulec, David Dubnau
A MecA paralog, YpbH, binds ClpC, affecting both competence and sporulation.
J Bacteriol: 2002, 184(8);2310-3
[PubMed:11914365] [WorldCat.org] [DOI] (P p)