SpeE

• Description: spermidine synthase
  
  

Gene name	speE
Synonyms	ywhF
Essential	no
Product	spermidine synthase
Function	spermidine, polyamine biosynthesis
Metabolic function and regulation of this protein in SubtiPathways: Cys, Met & Sulfate assimilation
MW, pI	31 kDa, 5.068
Gene length, protein length	828 bp, 276 aa
Immediate neighbours	speB, pbpG
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU37500

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Categories containing this gene/protein

miscellaneous metabolic pathways

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: S-adenosylmethioninamine + putrescine = 5'-S-methyl-5'-thioadenosine + spermidine (according to Swiss-Prot)

• Protein family: spermidine/spermine synthase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 1IY9

• UniProt: P70998

• KEGG entry: [3]

• E.C. number: 2.5.1.16

Expression and regulation

• Operon:
  • speE-speB PubMed
  • speE PubMed

• Sigma factor: SigA PubMed

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

A Sekowska, P Bertin, A Danchin
Characterization of polyamine synthesis pathway in Bacillus subtilis 168.
Mol Microbiol: 1998, 29(3);851-8
[PubMed:9723923] [WorldCat.org] [DOI] (P p)