KipA

• Description: antagonist of KipI, control of the phosphorelay
  
  

Gene name	kipA
Synonyms
Essential	no
Product	antagonist of KipI
Function	control of the phosphorelay, initiation of sporulation
Function and regulation of this protein in SubtiPathways: Phosphorelay
MW, pI	36 kDa, 5.465
Gene length, protein length	1011 bp, 337 aa
Immediate neighbours	kipI, kipR
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU04090

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Categories containing this gene/protein

phosphorelay

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: KipA-KipI PubMed

• Localization:

Database entries

• Structure:

• UniProt: Q7WY77

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ycsF-ycsG-ycsI-kipI-kipA-kipR-lipC PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:
  • KipR: transcription repression PubMed
  • TnrA: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

David A Jacques, David B Langley, Robert M G Hynson, Andrew E Whitten, Ann Kwan, J Mitchell Guss, Jill Trewhella
A novel structure of an antikinase and its inhibitor.
J Mol Biol: 2011, 405(1);214-26
[PubMed:21050859] [WorldCat.org] [DOI] (I p)

L Wang, R Grau, M Perego, J A Hoch
A novel histidine kinase inhibitor regulating development in Bacillus subtilis.
Genes Dev: 1997, 11(19);2569-79
[PubMed:9334321] [WorldCat.org] [DOI] (P p)