BioA

• Description: lysine-8-amino-7-oxononanoate aminotransferase
  
  

Gene name	bioA
Synonyms
Essential	no
Product	lysine-8-amino-7-oxononanoate aminotransferase
Function	biosynthesis of biotin
MW, pI	49 kDa, 5.32
Gene length, protein length	1344 bp, 448 aa
Immediate neighbours	bioF, bioW
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU30230

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: class-III pyridoxal-phosphate-dependent aminotransferase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 3DRD

• UniProt: P53555

• KEGG entry: [3]

• E.C. number: 2.6.1.62

Expression and regulation

• Operon: bioW-bioA-bioF-bioD-bioB-bioI-ytbQ PubMed

• Sigma factor:

• Regulation:
  • repressed in the presence of biotin (BirA) PubMed

• Regulatory mechanism:
  • BirA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: