HemZ

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  • Description: coproporphyrinogen III oxidase

Gene name hemZ
Synonyms yhaW, yhaV
Essential no
Product coproporphyrinogen III oxidase
Function heme biosynthesis
MW, pI 57 kDa, 5.899
Gene length, protein length 1503 bp, 501 aa
Immediate neighbours yhaX, yhaU
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
HemZ context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU09840

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Coproporphyrinogen-III + 2 S-adenosyl-L-methionine = protoporphyrinogen-IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine (according to Swiss-Prot)
  • Protein family: anaerobic coproporphyrinogen III oxidase family (according to Swiss-Prot)
  • Paralogous protein(s): hemN

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • induced under anaerobic conditions during growth in the presence of nitrate (no induction in the absence of terminal electron acceptor) (Fnr, ResD, ArfM) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References