RbsR

• Description: transcriptional repressor of the ribose operon
  
  

Gene name	rbsR
Synonyms
Essential	no
Product	transcriptional repressor (LacI family)
Function	regulation of ribose utilization
Metabolic function and regulation of this protein in SubtiPathways: Sugar catabolism
MW, pI	35 kDa, 5.577
Gene length, protein length	978 bp, 326 aa
Immediate neighbours	capB, rbsK
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU35910

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: PtsH-RbsR

• Localization:

Database entries

• Structure:

• Swiss prot entry: P36944

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: rbsR-rbsK-rbsD-rbsA-rbsC-rbsB

• Sigma factor: SigA

• Regulation: repressed by glucose (10-fold) (CcpA) PubMed
  • expressed upon transition into the stationary phase (AbrB) PubMed

• Regulatory mechanism: CcpA: transcription repression
  • AbrB: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

1. Blencke et al. (2003) Transcriptional profiling of gene expression in response to glucose in Bacillus subtilis: regulation of the central metabolic pathways. Metab Eng. 5: 133-149 PubMed
2. Woodson K, Devine KM. (1994) Analysis of a ribose transport operon from Bacillus subtilis. Microbiology. Aug;140 ( Pt 8): 1829-38. PubMed
3. Müller W, Horstmann N, Hillen W, Sticht H. (2006) The transcription regulator RbsR represents a novel interaction partner of the phosphoprotein HPr-Ser46-P in Bacillus subtilis. FEBS J. Mar;273(6): 1251-61. PubMed
4. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed