PdxK

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  • Description: pyridoxine, pyridoxal, and pyridoxamine kinase

Gene name pdxK
Synonyms ywdB, ipa-52r, thiD
Essential no
Product pyridoxine, pyridoxal, and pyridoxamine kinase
Function biosynthesis of pyridoxal phosphate
Gene expression levels in SubtiExpress: pdxK
Metabolic function and regulation of this protein in SubtiPathways:
PdxK
MW, pI 28 kDa, 4.922
Gene length, protein length 813 bp, 271 aa
Immediate neighbours ywzG, ywdA
Sequences Protein DNA DNA_with_flanks
Genetic context
ThiD context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
PdxK expression.png
























Categories containing this gene/protein

biosynthesis of cofactors

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU38020

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine (according to Swiss-Prot)
  • Protein family: thiD family (according to Swiss-Prot)
  • Paralogous protein(s): ThiD

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [3]

Additional information

  • subject to Clp-dependent proteolysis upon glucose starvation PubMed

Expression and regulation

  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information: subject to Clp-dependent proteolysis upon glucose starvation PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References