PgcA

• Description: alpha-phosphoglucomutase, required for UDP-glucose synthesis, inhibits FtsZ ring assembly (indirect effect due to a defect in UDP-glucose synthesis)
  
  

Gene name	pgcA
Synonyms	yhxB, gtaC, gtaE
Essential	no
Product	alpha-phosphoglucomutase
Function	interconversion of glucose 6-phosphate and alpha-glucose 1-phosphate
Gene expression levels in SubtiExpress: pgcA
Metabolic function and regulation of this protein in SubtiPathways: Lipid synthesis
MW, pI	62 kDa, 4.913
Gene length, protein length	1695 bp, 565 aa
Immediate neighbours	glpD, yhcY
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell wall synthesis, lipid metabolism/ other, phosphoproteins

The gene

Basic information

• Locus tag: BSU09310

Phenotypes of a mutant

• the inactivation of pgcA suppresses the poor and filametous growth of the yvcL zapA double mutant PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate (according to Swiss-Prot)

• Protein family: phosphohexose mutase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylated on ser/ thr/ tyr PubMed, PubMed

• Cofactors:

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P18159

• KEGG entry: [2]

• E.C. number: 5.4.2.2

Additional information

PgcA inhibits FtsZ ring assembly (indirect effect due to a defect in UDP-glucose synthesis)PubMed

Expression and regulation

• Operon:

• Expression browser: pgcA PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Massimiliano Marvasi, Pieter T Visscher, Lilliam Casillas Martinez
Exopolymeric substances (EPS) from Bacillus subtilis: polymers and genes encoding their synthesis.
FEMS Microbiol Lett: 2010, 313(1);1-9
[PubMed:20735481] [WorldCat.org] [DOI] (I p)