LctP

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  • Description: lactate permease, excretion

Gene name lctP
Synonyms ycgC
Essential no
Product L-lactate permease
Function lactate excretion
Gene expression levels in SubtiExpress: lctP
Metabolic function and regulation of this protein in SubtiPathways:
Central C-metabolism
MW, pI 57 kDa, 9.766
Gene length, protein length 1623 bp, 541 aa
Immediate neighbours ldh, mdr
Sequences Protein DNA DNA_with_flanks
Genetic context
LctP context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
LctP expression.png




























Categories containing this gene/protein

transporters/ other, carbon core metabolism, membrane proteins

This gene is a member of the following regulons

Rex regulon

The gene

Basic information

  • Locus tag: BSU03060

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: lactate permease family (according to Swiss-Prot)
  • Paralogous protein(s): LutP

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • induced under anaerobic conditions (Rex) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

You-Kwan Oh, Bernhard O Palsson, Sung M Park, Christophe H Schilling, Radhakrishnan Mahadevan
Genome-scale reconstruction of metabolic network in Bacillus subtilis based on high-throughput phenotyping and gene essentiality data.
J Biol Chem: 2007, 282(39);28791-28799
[PubMed:17573341] [WorldCat.org] [DOI] (P p)

Heike Reents, Richard Münch, Thorben Dammeyer, Dieter Jahn, Elisabeth Härtig
The Fnr regulon of Bacillus subtilis.
J Bacteriol: 2006, 188(3);1103-12
[PubMed:16428414] [WorldCat.org] [DOI] (P p)

Jonas T Larsson, Annika Rogstam, Claes von Wachenfeldt
Coordinated patterns of cytochrome bd and lactate dehydrogenase expression in Bacillus subtilis.
Microbiology (Reading): 2005, 151(Pt 10);3323-3335
[PubMed:16207915] [WorldCat.org] [DOI] (P p)

H Cruz Ramos, T Hoffmann, M Marino, H Nedjari, E Presecan-Siedel, O Dreesen, P Glaser, D Jahn
Fermentative metabolism of Bacillus subtilis: physiology and regulation of gene expression.
J Bacteriol: 2000, 182(11);3072-80
[PubMed:10809684] [WorldCat.org] [DOI] (P p)