FolB

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  • Description: dihydroneopterin aldolase

Gene name folB
Synonyms folA, yacE
Essential no
Product dihydroneopterin aldolase
Function biosynthesis of folate
Gene expression levels in SubtiExpress: folB
Metabolic function and regulation of this protein in SubtiPathways:
Folate
MW, pI 13 kDa, 5.228
Gene length, protein length 360 bp, 120 aa
Immediate neighbours sul, folK
Sequences Protein DNA DNA_with_flanks
Genetic context
FolB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
FolB expression.png




























Categories containing this gene/protein

biosynthesis of cofactors

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU00780

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde (according to Swiss-Prot)
  • Protein family: DHNA family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1U68 (from Staphylococcus aureus, 47% identity, 72% similarity) PubMed
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References