SufS

• Description: cysteine desulfurase, cysteine:SufU sulfuryl transferase
  
  

Gene name	sufS
Synonyms	yurW, csd
Essential	yes PubMed
Product	cysteine desulfurase
Function	formation of iron-sulfur clusters in proteins
Gene expression levels in SubtiExpress: sufS
Interactions involving this protein in SubtInteract: SufS
MW, pI	44 kDa, 5.199
Gene length, protein length	1218 bp, 406 aa
Immediate neighbours	sufU, sufD
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

iron metabolism, essential genes

The gene

Basic information

• Locus tag: BSU32690

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: transfer of iron to SufU PubMed

• Protein family: Csd subfamily (according to Swiss-Prot)

• Paralogous protein(s): NifS, YrvO, NifZ, YcbU

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: interaction with SufU enhances the activity of SufS 40-fold PubMed

• Interactions: SufS-SufU PubMed

• Localization:

Database entries

• Structure:

• UniProt: O32164

• KEGG entry: [2]

• E.C. number: 2.8.1.7

Expression and regulation

• Operon:

• Expression browser: sufS PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Bruna Selbach, Emily Earles, Patricia C Dos Santos
Kinetic analysis of the bisubstrate cysteine desulfurase SufS from Bacillus subtilis.
Biochemistry: 2010, 49(40);8794-802
[PubMed:20822158] [WorldCat.org] [DOI] (I p)

Alexander G Albrecht, Daili J A Netz, Marcus Miethke, Antonio J Pierik, Olaf Burghaus, Florian Peuckert, Roland Lill, Mohamed A Marahiel
SufU is an essential iron-sulfur cluster scaffold protein in Bacillus subtilis.
J Bacteriol: 2010, 192(6);1643-51
[PubMed:20097860] [WorldCat.org] [DOI] (I p)

Additional publications: PubMed