SirA

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  • Description: sporulation protein, inhibits DNA replication

Gene name sirA
Synonyms yneE, yoxF
Essential no
Product inhibitor of DNA replication
Function control of chromosome copy number
Gene expression levels in SubtiExpress: sirA
Interactions involving this protein in SubtInteract: SirA
MW, pI 17 kDa, 7.353
Gene length, protein length 444 bp, 148 aa
Immediate neighbours tkt, yneF
Sequences Protein DNA DNA_with_flanks
Genetic context
YneE context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
SirA expression.png
























Categories containing this gene/protein

DNA replication

This gene is a member of the following regulons

Spo0A regulon

The gene

yneE was renamed to sirA.

Basic information

  • Locus tag: BSU17900

Phenotypes of a mutant

"over-replication" during sporulation PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: interacts with DnaA and displaces it from the replication origin, resulting in inhibition of replication PubMed
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
    • expressed under conditions that trigger sporulation (Spo0A) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

sirA (sporulation inhibitor of replication) is activated by Spo0A~P and inhibits DNA replication during sporulation.

References

Reviews

Original publications