Sr1

• Description: small regulatory RNA controlling ahrC expression, peptide controlling the stability of the cggR-gapA mRNA
  
  

Gene name	sr1
Synonyms	ykzW
Essential	no
Product	small regulatory RNA/ regulatory peptide
Function	control of arginine metabolism and glycolysis
Gene expression levels in SubtiExpress: Sr1
Interactions involving this peptide in SubtInteract: YkzW
MW, pI	4.4 kDa, 3.89
Gene length, protein length	205 bp (RNA), 120 bp (ORF), 39 aa
Immediate neighbours	slp, speA
Gene sequence
Genetic context

Categories containing this gene/protein

biosynthesis/ acquisition of amino acids, utilization of amino acids, ncRNA

This gene is a member of the following regulons

CcpN regulon

The gene

Basic information

• Locus tag:

Database entries

• DBTBS entry: no entry

Additional information

Located between the slp and speA genes.

The RNA

Basic information/ Evolution

• Catalyzed reaction/ biological activity: hybridizes to ahrC mRNA and inhibits AhrC translation. PubMed

Extended information on the RNA

• Kinetic information

• Interactions: Binds ahrC mRNA PubMed

• Localization

Database entries

• Structure:

Additional information

Information on the structure of the RNA can be found in Heidrich et al., 2006

The peptide

Basic information/ Evolution

• Catalyzed reaction/ biological activity: the peptide controls the stability of the cggR-gapA mRNA PubMed

• Protein family: the peptide is conserved in bacilli

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • GapA-YkzW PubMed

• Localization:

Database entries

• Structure:

• UniProt: C0H410

• KEGG entry:

• E.C. number:

Expression and regulation

• Operon: sr1 PubMed

• Sigma factor: SigA PubMed

• Regulation: Repressed in the presence of glucose by CcpN PubMed

• Regulatory mechanism: transcription repression PubMed

• Additional information:

Biological materials

• Mutant: 168 sr1::cat, available in Brantl lab

• Expression vector:

• lacZ fusion:

Labs working on this gene/protein

Sabine Brantl, Bacterial Genetics, Friedrich-Schiller-University of Jena, Germany homepage