Med

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  • Description: lipoprotein, positive regulator of comK, stimulates KinD-dependent phosphorylation of Spo0A

Gene name med
Synonyms yjaW
Essential no
Product positive regulator of comK
Function regulation of competence
Metabolic function and regulation of this protein in SubtiPathways:
Protein secretion
MW, pI 35 kDa, 4.599
Gene length, protein length 951 bp, 317 aa
Immediate neighbours yjaV, comZ
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
Med context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
Med expression.png
























Categories containing this gene/protein

genetic competence

This gene is a member of the following regulons

Spo0A regulon

The gene

Basic information

  • Locus tag: BSU11300

Phenotypes of a mutant

  • impaired biofilm formation PubMed


Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: BMP lipoprotein family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed under conditions that trigger sporulation (Spo0A) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additonal publications: PubMed

Virginie Molle, Masaya Fujita, Shane T Jensen, Patrick Eichenberger, José E González-Pastor, Jun S Liu, Richard Losick
The Spo0A regulon of Bacillus subtilis.
Mol Microbiol: 2003, 50(5);1683-701
[PubMed:14651647] [WorldCat.org] [DOI] (P p)

Mitsuo Ogura, Hitoshi Hashimoto, Teruo Tanaka
Med, a cell-surface localized protein regulating a competence transcription factor gene, comK, in Bacillus subtilis.
Biosci Biotechnol Biochem: 2002, 66(4);892-6
[PubMed:12036071] [WorldCat.org] [DOI] (P p)

M Ogura, Y Ohshiro, S Hirao, T Tanaka
A new Bacillus subtilis gene, med, encodes a positive regulator of comK.
J Bacteriol: 1997, 179(20);6244-53
[PubMed:9335269] [WorldCat.org] [DOI] (P p)