GsaB

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  • Description: glutamate-1-semialdehyde aminotransferase

Gene name gsaB
Synonyms
Essential no
Product glutamate-1-semialdehyde aminotransferase
Function biosynthesis of heme
MW, pI 46 kDa, 5.644
Gene length, protein length 1287 bp, 429 aa
Immediate neighbours ygaE, ygaF
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
GsaB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
GsaB expression.png
























Categories containing this gene/protein

biosynthesis of cofactors

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU08710

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate (according to Swiss-Prot)
  • Protein family: HemL subfamily (according to Swiss-Prot)
  • Paralogous protein(s): HemL

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Honghua Ge, Xinhuai Lv, Jun Fan, Yongxiang Gao, Maikun Teng, Liwen Niu
Crystal structure of glutamate-1-semialdehyde aminotransferase from Bacillus subtilis with bound pyridoxamine-5'-phosphate.
Biochem Biophys Res Commun: 2010, 402(2);356-60
[PubMed:20946885] [WorldCat.org] [DOI] (I p)