PpsD

• Description: plipastatin synthetase
  
  

Gene name	ppsD
Synonyms
Essential	no
Product	plipastatin synthetase
Function	production of the antibacterial compound plipastatin
MW, pI	406 kDa, 5.347
Gene length, protein length	10809 bp, 3603 aa
Immediate neighbours	ppsE, ppsC
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

miscellaneous metabolic pathways, biosynthesis of antibacterial compounds

This gene is a member of the following regulons

AbrB regulon

The gene

Basic information

• Locus tag: BSU18310

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: ATP-dependent AMP-binding enzyme family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P94459

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: ppsA-ppsB-ppsC-ppsD-ppsE PubMed

• Expression browser: ppsD PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:
  • AbrB: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed

Maria Batool, Mohammad Hassan Khalid, Muhammad Nadeem Hassan, Hafeez Fauzia Yusuf
Homology modeling of an antifungal metabolite plipastatin synthase from the Bacillus subtilis 168.
Bioinformation: 2011, 7(8);384-7
[PubMed:22347779] [WorldCat.org] [DOI] (I p)

K Tsuge, T Ano, M Hirai, Y Nakamura, M Shoda
The genes degQ, pps, and lpa-8 (sfp) are responsible for conversion of Bacillus subtilis 168 to plipastatin production.
Antimicrob Agents Chemother: 1999, 43(9);2183-92
[PubMed:10471562] [WorldCat.org] [DOI] (P p)

Valentina Tosato, Alessandra M Albertini, Michela Zotti, Sabrina Sonda, Carlo V Bruschi
Sequence completion, identification and definition of the fengycin operon in Bacillus subtilis 168.
Microbiology (Reading): 1997, 143 ( Pt 11);3443-3450
[PubMed:9387222] [WorldCat.org] [DOI] (P p)