Fra

From SubtiWiki
Revision as of 10:23, 12 July 2011 by Jstuelk (talk | contribs)
Jump to: navigation, search
  • Description: frataxin-like protein, required for the biosynthesis of iron-sulfur clusters

Gene name fra
Synonyms ydhG
Essential no
Product frataxin-like protein
Function intracellular iron channeling, biosynthesis of iron-sulfur clusters
MW, pI 14 kDa, 5.377
Gene length, protein length 369 bp, 123 aa
Immediate neighbours phoB, ydhH
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YdhG context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

iron metabolism

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU05750

Phenotypes of a mutant

  • severe growth phenotype associated with a broadly disturbed iron homeostasis PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: transfers iron onto the B. subtilis SUF system (SufU-SufS) for iron-sulfur cluster biosynthesis PubMed
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s): Fe(2+) is bound with high affinity PubMed
  • Effectors of protein activity:
  • Localization:

Database entries

  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Alexander G Albrecht, Hannes Landmann, David Nette, Olaf Burghaus, Florian Peuckert, Andreas Seubert, Marcus Miethke, Mohamed A Marahiel
The frataxin homologue Fra plays a key role in intracellular iron channeling in Bacillus subtilis.
Chembiochem: 2011, 12(13);2052-61
[PubMed:21744456] [WorldCat.org] [DOI] (I p)

Wenbin Qi, J A Cowan
A structural and functional homolog supports a general role for frataxin in cellular iron chemistry.
Chem Commun (Camb): 2010, 46(5);719-21
[PubMed:20087498] [WorldCat.org] [DOI] (I p)