PanB
- Description: 3-methyl-2-oxobutanoate hydroxymethyltransferase
| Gene name | panB |
| Synonyms | |
| Essential | no |
| Product | 3-methyl-2-oxobutanoate hydroxymethyltransferase |
| Function | biosynthesis of coenzyme A |
| Metabolic function and regulation of this protein in SubtiPathways: Coenzyme A | |
| MW, pI | 29 kDa, 5.282 |
| Gene length, protein length | 831 bp, 277 aa |
| Immediate neighbours | panC, birA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU22430
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = tetrahydrofolate + 2-dehydropantoate (according to Swiss-Prot)
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure: 3EZ4 (from Burkholderia pseudomallei, 44% identity, 64% similarity)
- UniProt: P52996
- KEGG entry: [2]
- E.C. number: 2.1.2.11
Additional information
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
