PyrR

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  • Description: transcriptional antiterminator of the pyr operon

Gene name pyrR
Synonyms
Essential no
Product transcriptional antiterminator with minor uracil
phosphoribosyltransferase activity
Function regulation of pyrimidine biosynthesis
Metabolic function and regulation of this protein in SubtiPathways:
Nucleotides (regulation)
MW, pI 20 kDa, 4.991
Gene length, protein length 543 bp, 181 aa
Immediate neighbours ylyB, pyrP
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
PyrR context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU15470

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)
  • Protein family: PyrR subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization:

Database entries

  • Structure: 1A3C (dimeric form)
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • induced in the absence of uridine nucleotides (PyrR) PubMed
  • Regulatory mechanism:
    • PyrR: RNA switch, transcription termination/ antitermination (in the presence of uridine nucleotides: termination, in their absence: antitermination) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References