MurJ

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  • Description: lipid II flippase

Gene name murJ
Synonyms ytgP
Essential no
Product lipid II flippase
Function export of lipid II
Gene expression levels in SubtiExpress: murJ
MW, pI 59 kDa, 10.089
Gene length, protein length 1632 bp, 544 aa
Immediate neighbours ytzG, ytfP
Sequences Protein DNA DNA_with_flanks
Genetic context
YtgP context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YtgP expression.png















Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU30050

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Alexander J Meeske, Lok-To Sham, Harvey Kimsey, Byoung-Mo Koo, Carol A Gross, Thomas G Bernhardt, David Z Rudner
MurJ and a novel lipid II flippase are required for cell wall biogenesis in Bacillus subtilis.
Proc Natl Acad Sci U S A: 2015, 112(20);6437-42
[PubMed:25918422] [WorldCat.org] [DOI] (I p)

Allison Fay, Jonathan Dworkin
Bacillus subtilis homologs of MviN (MurJ), the putative Escherichia coli lipid II flippase, are not essential for growth.
J Bacteriol: 2009, 191(19);6020-8
[PubMed:19666716] [WorldCat.org] [DOI] (I p)

Pradeep Vasudevan, Jessica McElligott, Christa Attkisson, Michael Betteken, David L Popham
Homologues of the Bacillus subtilis SpoVB protein are involved in cell wall metabolism.
J Bacteriol: 2009, 191(19);6012-9
[PubMed:19648239] [WorldCat.org] [DOI] (I p)