ComFB

• Description: late competence gene
  
  

Gene name	comFB
Synonyms
Essential	no
Product	unknown
Function	compentence
Gene expression levels in SubtiExpress: comFB
MW, pI	10 kDa, 4.827
Gene length, protein length	294 bp, 98 aa
Immediate neighbours	comFC, comFA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

genetic competence

This gene is a member of the following regulons

ComK regulon

The gene

Basic information

• Locus tag: BSU35460

Database entries

• BsubCyc: BSU35460

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:
  • Zn PubMed

• Effectors of protein activity:

• Interactions:

• Localization:
  • forms dimers PubMed
  • cytoplasma PubMed
  • localizes to one or both cell poles PubMed

Database entries

• BsubCyc: BSU35460

• Structure: 4WAI PubMed

• UniProt: P39146

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: comFA-comFB-comFC-yvyF-flgM-flgN-flgK-flgL PubMed

• Expression browser: comFB PubMed

• Sigma factor: comFA: SigA PubMed

• Regulation:

• Regulatory mechanism:
  • ComK: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Tatyana A Sysoeva, Lukas B Bane, Daphne Y Xiao, Baundauna Bose, Scott S Chilton, Rachelle Gaudet, Briana M Burton
Structural characterization of the late competence protein ComFB from Bacillus subtilis.
Biosci Rep: 2015, 35(2);
[PubMed:25423369] [WorldCat.org] [DOI] (I e)

Miriam Kaufenstein, Martin van der Laan, Peter L Graumann
The three-layered DNA uptake machinery at the cell pole in competent Bacillus subtilis cells is a stable complex.
J Bacteriol: 2011, 193(7);1633-42
[PubMed:21278288] [WorldCat.org] [DOI] (I p)

Hanne Jarmer, Randy Berka, Steen Knudsen, Hans H Saxild
Transcriptome analysis documents induced competence of Bacillus subtilis during nitrogen limiting conditions.
FEMS Microbiol Lett: 2002, 206(2);197-200
[PubMed:11814663] [WorldCat.org] [DOI] (P p)

J A Londoño-Vallejo, D Dubnau
comF, a Bacillus subtilis late competence locus, encodes a protein similar to ATP-dependent RNA/DNA helicases.
Mol Microbiol: 1993, 9(1);119-31
[PubMed:8412657] [WorldCat.org] [DOI] (P p)