PurC

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  • Description: phosphoribosylaminoimidazole succinocarboxamide synthase

Gene name purC
Synonyms
Essential no
Product phosphoribosylaminoimidazole
succinocarboxamide synthase
Function purine biosynthesis
Gene expression levels in SubtiExpress: purC
Metabolic function and regulation of this protein in SubtiPathways:
purC
MW, pI 27 kDa, 4.875
Gene length, protein length 723 bp, 241 aa
Immediate neighbours purB, purS
Sequences Protein DNA DNA_with_flanks
Genetic context
PurC context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
PurC expression.png















Categories containing this gene/protein

biosynthesis/ acquisition of nucleotides, most abundant proteins

This gene is a member of the following regulons

G-box, PurR regulon

The gene

Basic information

  • Locus tag: BSU06450

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (according to Swiss-Prot)
  • Protein family: SAICAR synthetase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity:

Database entries

  • Structure: 1KUT (from Thermotoga maritima, 40% identity, 57% similarity) PubMed
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • repressed in the presence of purine nucleotides (PurR) PubMed
    • repressed in the presence of adenine or adenosine(PurR) PubMed
    • repressed in the presence of guanine(G-box) PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References