EtfA

• Description: electron transfer flavoprotein (alpha subunit)
  
  

Gene name	etfA
Synonyms
Essential	no
Product	electron transfer flavoprotein (alpha subunit)
Function	fatty acid degradation, calcium carbonate biomineralization
Gene expression levels in SubtiExpress: etfA
Metabolic function and regulation of this protein in SubtiPathways: etfA
MW, pI	34 kDa, 4.652
Gene length, protein length	975 bp, 325 aa
Immediate neighbours	abf2, etfB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

electron transport/ other, utilization of lipids

This gene is a member of the following regulons

CcpA regulon, FadR regulon

The gene

Basic information

• Locus tag: BSU28520

Database entries

• BsubCyc: BSU28520

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: ETF alpha-subunit/fixB family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: EtfA-EtfB (based on function)

• Localization:

Database entries

• BsubCyc: BSU28520

• Structure:

• UniProt: P94551

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • lcfA-fadR-fadB-etfB-etfA PubMed
  • fadR-fadB-etfB-etfA PubMed

• Expression browser: etfA PubMed

• Sigma factor:
  • lcfA: SigA PubMed
  • fadR: SigA PubMed

• Regulation:
  • induced by long-chain fatty acids (FadR) PubMed
  • subject to carbon catabolite repression (CcpA-HPr(Ser-P) PubMed

• Regulatory mechanism:
  • FadR: transcription repression PubMed
  • CcpA-HPr(Ser-P): transcription repression PubMed

• Additional information:

Biological materials

• Mutant:
  • 1A856 ( etfA::cat), PubMed, available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Yasutaro Fujita, Hiroshi Matsuoka, Kazutake Hirooka
Regulation of fatty acid metabolism in bacteria.
Mol Microbiol: 2007, 66(4);829-39
[PubMed:17919287] [WorldCat.org] [DOI] (P p)