YueB

• Description: membrane protein, part of the type VII protein secretion system YukD-YukC-YukB-YueB-YueC, receptor for phage SPPI
  
  

Gene name	yueB
Synonyms
Essential	no
Product	part of the type VII protein secretion system, receptor for phage SPPI
Function	export of YukE
Gene expression levels in SubtiExpress: yueB
MW, pI	119 kDa, 4.302
Gene length, protein length	3228 bp, 1076 aa
Immediate neighbours	yueC, yukB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

phage-related functions, protein secretion, membrane proteins

This gene is a member of the following regulons

DegU regulon

The gene

Basic information

• Locus tag: BSU31860

Phenotypes of a mutant

• resistance to phage SPPI PubMed

Database entries

• BsubCyc: BSU31860

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • receptor for phage SPP1 PubMed
  • required for depolarization of the cytoplasmic membrane upon binding of phage SPP1 PubMed

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • YueB is a member of a suspected group of hubs proteins that were suggested to be involved in a large number of interactions PubMed

• Localization:
  • cell membrane PubMed, localizes preferentially to the cell poles PubMed
  • exposed to the surface PubMed
  • cytoplasm (homogeneous) PubMed

Database entries

• BsubCyc: BSU31860

• Structure:

• UniProt: O32101

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: yukE-yukD-yukC-yukB-yueB-yueC PubMed

• Expression browser: yueB PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • not expressed in the lab strain 168, due to lack of DegU-P PubMed
  • expressed in the stationary phase PubMed

• Regulatory mechanism:
  • DegU-P: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Roxane Simeone, Daria Bottai, Roland Brosch
ESX/type VII secretion systems and their role in host-pathogen interaction.
Curr Opin Microbiol: 2009, 12(1);4-10
[PubMed:19155186] [WorldCat.org] [DOI] (I p)

Mark J Pallen
The ESAT-6/WXG100 superfamily -- and a new Gram-positive secretion system?
Trends Microbiol: 2002, 10(5);209-12
[PubMed:11973144] [WorldCat.org] [DOI] (P p)