Register here for the SubtiWiki workshop at the 22nd International Conference on Bacilli & Gram-Positive Bacteria in Bloomington in June 2024 (conference website)!
We will show you how to use the newest features of SubtiWiki's next release, such as visualization of conserved gene arrangements and dedicated metabolite pages! You can get a sneak-peek here: corewiki.uni-goettingen.de
yukD
168
Ubiquitin-like protein, part of the type VII protein secretion system [protein|3CC3E197848E9688413C15CEA7DDCF0A7120A920|yukD]-[protein|3FE4A91C7D0B43C8704391F2F9493852B3AED9B0|essB]-[protein|6007664F3D979B4D8D4662C7F6E5CF2F489268E3|yukB]-[protein|0A38B2E900532C9950DE6E629F5EB21D64E18B55|yueB]-[protein|DA52C4CD130F32734E01A52F2F395127D2260F61|yueC], putative bacteriocin
function
export of [protein|50D2A03E2D7B5D461540FD157377E0D37F771888|yukE]
product
ubiquitin-like protein, part of the type VII protein secretion system, putative bacteriocin
Genomic Context
This gene is a member of the following
regulons
Gene
Coordinates
3,275,832 3,276,071
Phenotypes of a mutant
loss of secretion of [protein|50D2A03E2D7B5D461540FD157377E0D37F771888|yukE] [Pubmed|24798022]
Advertisement
The protein
Catalyzed reaction/ biological activity
export of [protein|50D2A03E2D7B5D461540FD157377E0D37F771888|yukE] [Pubmed|24828531,23861817]
secretion and delivery of [wiki|LXG domain] toxins [pubmed|34280190]
Protein family
EsaB family (single member, according to UniProt)
Structure
Expression and Regulation
Operons
genes
[gene|50D2A03E2D7B5D461540FD157377E0D37F771888|yukE]-[gene|3CC3E197848E9688413C15CEA7DDCF0A7120A920|yukD]-[gene|3FE4A91C7D0B43C8704391F2F9493852B3AED9B0|essB]-[gene|6007664F3D979B4D8D4662C7F6E5CF2F489268E3|yukB]-[gene|0A38B2E900532C9950DE6E629F5EB21D64E18B55|yueB]-[gene|DA52C4CD130F32734E01A52F2F395127D2260F61|yueC]-[gene|B258CA26B0EC2310475FCCD67F1F196857FC0004|yueD]
description
[Pubmed|22383849]
regulation
expressed in the stationary phase [Pubmed|23861817]
expression is reduced in motile cells as compared to non-motile cells [pubmed|33782055]
regulatory mechanism
[protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|degU]: activation, [protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|degU]-P, [Pubmed|23861817], in [regulon|protein:D343D2096664A972026D911E7A17A35C7B1CD1C9|degU regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|22383849], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Open in new tab
[gene|50D2A03E2D7B5D461540FD157377E0D37F771888|yukE]→[gene|B258CA26B0EC2310475FCCD67F1F196857FC0004|yueD]
2024-05-16 09:12:53
Jstuelk
95
BB0E1B9684F16E121BAA022EF986B0285FB41FA7
CDC40F8A7006CF56CF9A6155897E8BD27FFEC7AA
Biological materials
Mutant
MGNA-A627 (yukD::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/627 NBRP B. subtilis, Japan]
BKE31900 ([gene|3CC3E197848E9688413C15CEA7DDCF0A7120A920|yukD]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE31900 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTAGGATCACCCTTACA, downstream forward: _UP4_ATATTATGAAAGGATCTGGT
BKK31900 ([gene|3CC3E197848E9688413C15CEA7DDCF0A7120A920|yukD]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK31900 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTAGGATCACCCTTACA, downstream forward: _UP4_ATATTATGAAAGGATCTGGT
References
Reviews
Original Publications
15576783,16845009,22383849,23861817,15978580,24798022,34280190,36154281