ArgH

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  • Description: argininosuccinate lyase

Gene name argH
Synonyms
Essential no
Product argininosuccinate lyase
Function biosynthesis of arginine
Gene expression levels in SubtiExpress: argH
Metabolic function and regulation of this protein in SubtiPathways:
argH
MW, pI 51 kDa, 4.859
Gene length, protein length 1383 bp, 461 aa
Immediate neighbours ytzD, argG
Sequences Protein DNA DNA_with_flanks
Genetic context
ArgH context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
ArgH expression.png




























Categories containing this gene/protein

biosynthesis/ acquisition of amino acids

This gene is a member of the following regulons

AhrC regulon

The gene

Basic information

  • Locus tag: BSU29440

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

  • A mutation was found in this gene after evolution under relaxed selection for sporulation PubMed

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: 2-(N(omega)-L-arginino)succinate = fumarate + L-arginine (according to Swiss-Prot)
  • Protein family: Argininosuccinate lyase subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1TJ7 (from Escherichia coli, 47% identity, 64% similarity) PubMed
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
    • repressed by casamino acids PubMed
    • repressed by arginine (AhrC)
  • Regulatory mechanism:
    • AhrC: transcription repression
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References