NadR

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  • Description: transcriptional repressor of genes involved in NAD biosynthesis

Gene name nadR
Synonyms yrxA
Essential no
Product transcriptional repressor
Function regulation of NAD biosynthesis
Gene expression levels in SubtiExpress: nadR
MW, pI 19 kDa, 5.759
Gene length, protein length 534 bp, 178 aa
Immediate neighbours nifS, pheA
Sequences Protein DNA DNA_with_flanks
Genetic context
YrxA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
NadR expression.png
























Categories containing this gene/protein

biosynthesis of cofactors, transcription factors and their control

This gene is a member of the following regulons

NadR regulon

The NadR regulon:

The gene

Basic information

  • Locus tag: BSU27890

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed in the presence of nicotinic acid (NadR) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Alessandra Albertini, University of Pavia, Italy homepage

Your additional remarks

References

Dmitry A Rodionov, Xiaoqing Li, Irina A Rodionova, Chen Yang, Leonardo Sorci, Etienne Dervyn, Dariusz Martynowski, Hong Zhang, Mikhail S Gelfand, Andrei L Osterman
Transcriptional regulation of NAD metabolism in bacteria: genomic reconstruction of NiaR (YrxA) regulon.
Nucleic Acids Res: 2008, 36(6);2032-46
[PubMed:18276644] [WorldCat.org] [DOI] (I p)

Paola Rossolillo, Ilaria Marinoni, Elisa Galli, Anna Colosimo, Alessandra M Albertini
YrxA is the transcriptional regulator that represses de novo NAD biosynthesis in Bacillus subtilis.
J Bacteriol: 2005, 187(20);7155-60
[PubMed:16199587] [WorldCat.org] [DOI] (P p)

D Sun, P Setlow
Cloning, nucleotide sequence, and regulation of the Bacillus subtilis nadB gene and a nifS-like gene, both of which are essential for NAD biosynthesis.
J Bacteriol: 1993, 175(5);1423-32
[PubMed:8444804] [WorldCat.org] [DOI] (P p)