Pdp

• Description: pyrimidine nucleoside phosphorylase
  
  

Gene name	pdp
Synonyms
Essential	no
Product	pyrimidine nucleoside phosphorylase
Function	pyrimidine interconversion
Gene expression levels in SubtiExpress: pdp
Metabolic function and regulation of this protein in SubtiPathways: Nucleoside catabolism, Nucleotides (regulation)
MW, pI	46 kDa, 4.765
Gene length, protein length	1299 bp, 433 aa
Immediate neighbours	hutM, nupC
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

utilization of nucleotides

This gene is a member of the following regulons

CcpA regulon, DeoR regulon

The gene

Basic information

• Locus tag: BSU39400

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: A pyrimidine nucleoside + phosphate = a pyrimidine base + alpha-D-ribose 1-phosphate (according to Swiss-Prot)

• Protein family: thymidine/pyrimidine-nucleoside phosphorylase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 1BRW (Geobacillus stearothermophilus)

• UniProt: P39142

• KEGG entry: [3]

• E.C. number: 2.4.2.2

Expression and regulation

• Operon: dra-nupC-pdp PubMed

• Expression browser: pdp PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed by glucose (CcpA) PubMed
  • induced by deoxynucleotides (DeoR) PubMed

• Regulatory mechanism:
  • CcpA: transcription repression PubMed
  • DeoR: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: