CoaA

• Description: probable pantothenate kinase
  
  

Gene name	coaA
Synonyms	yqjS
Essential	no
Product	probable pantothenate kinase
Function	biosynthesis of coenzyme A
Gene expression levels in SubtiExpress: coaA
Metabolic function and regulation of this protein in SubtiPathways: Coenzyme A
MW, pI	36 kDa, 5.894
Gene length, protein length	957 bp, 319 aa
Immediate neighbours	yqjT, dsdA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis of cofactors

The gene

Basic information

• Locus tag: BSU23760

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate (according to Swiss-Prot)

• Protein family: prokaryotic pantothenate kinase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 1SQ5 (from Escherichia coli, 49% identity, 67% similarity) PubMed

• UniProt: P54556

• KEGG entry: [3]

• E.C. number: 2.7.1.33

Expression and regulation

• Operon: yqjP-yqjQ-dsdA-coaA-yqjT (according to DBTBS)

• Expression browser: coaA PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

W J Song, S Jackowski
Cloning, sequencing, and expression of the pantothenate kinase (coaA) gene of Escherichia coli.
J Bacteriol: 1992, 174(20);6411-7
[PubMed:1328157] [WorldCat.org] [DOI] (P p)