Fra

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  • Description: frataxin-like protein, required for the biosynthesis of iron-sulfur clusters

Gene name fra
Synonyms ydhG
Essential no
Product frataxin-like protein
Function intracellular iron channeling, biosynthesis of iron-sulfur clusters
Gene expression levels in SubtiExpress: fra
Interactions involving this protein in SubtInteract: Fra
MW, pI 14 kDa, 5.377
Gene length, protein length 369 bp, 123 aa
Immediate neighbours phoB, ydhH
Sequences Protein DNA DNA_with_flanks
Genetic context
YdhG context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
Fra expression.png
























Categories containing this gene/protein

iron metabolism

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU05750

Phenotypes of a mutant

  • severe growth phenotype associated with a broadly disturbed iron homeostasis PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: transfers iron onto the B. subtilis SUF system (SufU-SufS) for iron-sulfur cluster biosynthesis PubMed
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s): Fe(2+) is bound with high affinity PubMed
  • Effectors of protein activity:

Database entries

  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed

Wenbin Qi, J A Cowan
A structural and functional homolog supports a general role for frataxin in cellular iron chemistry.
Chem Commun (Camb): 2010, 46(5);719-21
[PubMed:20087498] [WorldCat.org] [DOI] (I p)