YtaG

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  • Description: dephospho-CoA kinase

Gene name ytaG
Synonyms coaE
Essential yes PubMed
Product dephospho-CoA kinase
Function synthesis of coenzyme A
Gene expression levels in SubtiExpress: ytaG
Metabolic function and regulation of this protein in SubtiPathways:
Coenzyme A
MW, pI 21 kDa, 4.858
Gene length, protein length 591 bp, 197 aa
Immediate neighbours ytbE, ytaF
Sequences Protein DNA Advanced_DNA
Genetic context
YtaG context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YtaG expression.png















Categories containing this gene/protein

biosynthesis of cofactors, essential genes, phosphoproteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU29060

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + 3'-dephospho-CoA = ADP + CoA (according to Swiss-Prot)
  • Protein family: coaE family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: phosphorylated on ser/ thr/ tyr PubMed
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure: 1N3B (from Escherichia coli, 40% identity, 60% similarity) PubMed
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Alain Lévine, Françoise Vannier, Cédric Absalon, Lauriane Kuhn, Peter Jackson, Elaine Scrivener, Valérie Labas, Joëlle Vinh, Patrick Courtney, Jérôme Garin, Simone J Séror
Analysis of the dynamic Bacillus subtilis Ser/Thr/Tyr phosphoproteome implicated in a wide variety of cellular processes.
Proteomics: 2006, 6(7);2157-73
[PubMed:16493705] [WorldCat.org] [DOI] (P p)

Nicholas O'Toole, João A R G Barbosa, Yunge Li, Li-Wei Hung, Allan Matte, Miroslaw Cygler
Crystal structure of a trimeric form of dephosphocoenzyme A kinase from Escherichia coli.
Protein Sci: 2003, 12(2);327-36
[PubMed:12538896] [WorldCat.org] [DOI] (P p)

P Mishra, P K Park, D G Drueckhammer
Identification of yacE (coaE) as the structural gene for dephosphocoenzyme A kinase in Escherichia coli K-12.
J Bacteriol: 2001, 183(9);2774-8
[PubMed:11292795] [WorldCat.org] [DOI] (P p)

Alia Lapidus, Nathalie Galleron, Alexei Sorokin, S Dusko Ehrlich
Sequencing and functional annotation of the Bacillus subtilis genes in the 200 kb rrnB-dnaB region.
Microbiology (Reading): 1997, 143 ( Pt 11);3431-3441
[PubMed:9387221] [WorldCat.org] [DOI] (P p)