GlnL

• Description: two-component response regulator, regulation of the glsA-glnT operon
  
  

Gene name	glnL
Synonyms	ycbB, yzgB
Essential	no
Product	two-component response regulator
Function	regulation of the glsA-glnT operon
Gene expression levels in SubtiExpress: glnL
Interactions involving this protein in SubtInteract: GlnL
MW, pI	35 kDa, 7.02
Gene length, protein length	942 bp, 314 aa
Immediate neighbours	glnK, ycbC
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis/ acquisition of amino acids, utilization of amino acids, transcription factors and their control, phosphoproteins

The GlnL regulon:

• glsA-glnT

The gene

Basic information

• Locus tag: BSU02450

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylated by GlnK on an Asp residue

• Cofactor(s):

• Effectors of protein activity: phosphorylation likely affects DNA-binding activity

• Interactions: GlnK-GlnL

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P40759

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: glnL PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Takenori Satomura, Daisuke Shimura, Kei Asai, Yoshito Sadaie, Kazutake Hirooka, Yasutaro Fujita
Enhancement of glutamine utilization in Bacillus subtilis through the GlnK-GlnL two-component regulatory system.
J Bacteriol: 2005, 187(14);4813-21
[PubMed:15995196] [WorldCat.org] [DOI] (P p)

C Fabret, V A Feher, J A Hoch
Two-component signal transduction in Bacillus subtilis: how one organism sees its world.
J Bacteriol: 1999, 181(7);1975-83
[PubMed:10094672] [WorldCat.org] [DOI] (P p)