ArgG

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  • Description: argininosuccinate synthase, reversible

Gene name argG
Synonyms
Essential no
Product argininosuccinate synthase, reversible
Function biosynthesis of arginine
Gene expression levels in SubtiExpress: argG
Metabolic function and regulation of this protein in SubtiPathways:
Ammonium/ glutamate
MW, pI 44 kDa, 5.028
Gene length, protein length 1209 bp, 403 aa
Immediate neighbours argH, moaB
Sequences Protein DNA Advanced_DNA
Genetic context
ArgG context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
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Categories containing this gene/protein

biosynthesis/ acquisition of amino acids, phosphoproteins

This gene is a member of the following regulons

AhrC regulon

The gene

Basic information

  • Locus tag: BSU29450

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate (according to Swiss-Prot)
  • Protein family: Type 1 subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
    • S-cysteinylation after diamide stress (C187) PubMed
    • phosphorylated on Arg-262 PubMed
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1KH1 (from Thermus thermophilus, 44% identity, 65% similarity) PubMed
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
    • repressed by casamino acids PubMed
    • repressed by arginine (AhrC)
  • Regulatory mechanism:
    • AhrC: transcription repression
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References