KdgA

• Description: 2-dehydro-3-deoxy-phosphogluconate aldolase
  
  

Gene name	kdgA
Synonyms
Essential	no
Product	2-dehydro-3-deoxy-phosphogluconate aldolase
Function	utilization of galacturonic acid
Gene expression levels in SubtiExpress: kdgA
MW, pI	20 kDa, 5.273
Gene length, protein length	588 bp, 196 aa
Immediate neighbours	kdgT, kdgK
Sequences	Protein DNA Advanced_DNA
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

utilization of specific carbon sources, membrane proteins

This gene is a member of the following regulons

CcpA regulon, KdgR regulon

The gene

Basic information

• Locus tag: BSU22100

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate (according to Swiss-Prot)

• Protein family: anti-sigma-factor family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P50846

• KEGG entry: [3]

• E.C. number: 4.1.3.16

Expression and regulation

• Operon: kdgR-kdgK-kdgA-kdgT PubMed

• Expression browser: kdgA PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced by galacturonate (KdgR) PubMed
  • repressed by glucose (CcpA) PubMed

• Regulatory mechanism:
  • KdgR: transcription repression PubMed
  • CcpA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Petar Pujic, Rozenn Dervyn, Alexei Sorokin, S Dusko Ehrlich
The kdgRKAT operon of Bacillus subtilis: detection of the transcript and regulation by the kdgR and ccpA genes.
Microbiology (Reading): 1998, 144 ( Pt 11);3111-3118
[PubMed:9846747] [WorldCat.org] [DOI] (P p)