MurB

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  • Description: UDP-N-acetylenolpyruvoylglucosamine reductase

Gene name murB
Synonyms ylxC
Essential yes PubMed
Product UDP-N-acetylenolpyruvoylglucosamine reductase
Function peptidoglycan precursor biosynthesis
Gene expression levels in SubtiExpress: murB
Metabolic function and regulation of this protein in SubtiPathways:
Cell wall
MW, pI 32 kDa, 6.087
Gene length, protein length 909 bp, 303 aa
Immediate neighbours murG, divIB
Sequences Protein DNA Advanced_DNA
Genetic context
MurB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
MurB expression.png




























Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, sporulation proteins, cell envelope stress proteins (controlled by SigM, V, W, X, Y), essential genes

This gene is a member of the following regulons

SigE regulon, SigM regulon, SpoIIID regulon

The gene

Basic information

  • Locus tag: BSU15230

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH (according to Swiss-Prot)
  • Protein family: FAD-binding PCMH-type domain (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 2GQU (from Thermus caldophilus, 38% identity, 55% similarity) PubMed
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • expressed during vegatative growth, then switched off, and again expressed during sporulation in the mother cell (SigE) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Adriano Henriques, Lisbon, Portugal homepage

Your additional remarks

References