LipM

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  • Description: octanoyltransferase

Gene name lipM
Synonyms yqhM
Essential no
Product octanoyltransferase
Function biosynthesis of lipoic acid
MW, pI 32 kDa, 5.934
Gene length, protein length 834 bp, 278 aa
Immediate neighbours mntR, yqhL
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YqhM context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

biosynthesis of cofactors

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU24530

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • transfers the octanoyl moiety from octanoyl-acyl carrier protein to the lipoyl domains of the 2-oxoacid dehydrogenases via a thioester-linked octanoyl-LipM intermediate PubMed
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation: induced by valine PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Quin H Christensen, John E Cronan
Lipoic acid synthesis: a new family of octanoyltransferases generally annotated as lipoate protein ligases.
Biochemistry: 2010, 49(46);10024-36
[PubMed:20882995] [WorldCat.org] [DOI] (I p)