ImmR

• Description: transcriptional repressor, controls expression of genes of the mobile genetic element ICEBs1, induction by the SOS response or the RapI-PhrI sensory system
  
  

Gene name	immR
Synonyms	ydcN
Essential	no
Product	transcriptional regulator (phage-related) (Xre family)
Function	control of transfer of the mobile genetic element ICEBs1
MW, pI	14 kDa, 4.989
Gene length, protein length	381 bp, 127 aa
Immediate neighbours	immA, xis
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU04820

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

Categories containing this gene/protein

transcription factors and their control, mobile genetic elements

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: binding of RapI to ImmR results in loss of DNA-binding activity of ImmR and subsequently in induction of ImmR-repressed genes PubMed

• Interactions: ImmA-ImmR PubMed, RapI-ImmR PubMed

• Localization:

Database entries

• Structure:

• UniProt: P96631

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information: ImmR is degraded by the anti-repressor ImmA PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Baundauna Bose, Alan D Grossman
Regulation of horizontal gene transfer in Bacillus subtilis by activation of a conserved site-specific protease.
J Bacteriol: 2011, 193(1);22-9
[PubMed:21036995] [WorldCat.org] [DOI] (I p)

Baundauna Bose, Jennifer M Auchtung, Catherine A Lee, Alan D Grossman
A conserved anti-repressor controls horizontal gene transfer by proteolysis.
Mol Microbiol: 2008, 70(3);570-82
[PubMed:18761623] [WorldCat.org] [DOI] (I p)

Jennifer M Auchtung, Catherine A Lee, Katherine L Garrison, Alan D Grossman
Identification and characterization of the immunity repressor (ImmR) that controls the mobile genetic element ICEBs1 of Bacillus subtilis.
Mol Microbiol: 2007, 64(6);1515-28
[PubMed:17511812] [WorldCat.org] [DOI] (P p)