Difference between revisions of "ComFB"

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* '''[[Cofactors]]:'''
 
* '''[[Cofactors]]:'''
 +
** Zn {{PubMed|25423369}}
  
 
* '''Effectors of protein activity:'''
 
* '''Effectors of protein activity:'''
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* '''[[Localization]]:'''
 
* '''[[Localization]]:'''
 +
** forms dimers {{PubMed|25423369}}
 +
** cytoplasma {{PubMed|25423369}}
 
** localizes to one or both cell poles {{PubMed|21278288}}
 
** localizes to one or both cell poles {{PubMed|21278288}}
 +
  
 
=== Database entries ===
 
=== Database entries ===
 
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU35460&redirect=T BSU35460]
 
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU35460&redirect=T BSU35460]
  
* '''Structure:'''
+
* '''Structure:''' [http://pdb.org/pdb/search/structidSearch.do?structureId=4WAI 4WAI] {{PubMed|25423369}}
  
 
* '''UniProt:''' [http://www.uniprot.org/uniprot/P39146 P39146]
 
* '''UniProt:''' [http://www.uniprot.org/uniprot/P39146 P39146]
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=References=
 
=References=
  
<pubmed>11814663,8412657,21278288, </pubmed>
+
<pubmed>11814663,8412657,21278288, 25423369 </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 10:23, 26 November 2014

  • Description: late competence gene

Gene name comFB
Synonyms
Essential no
Product unknown
Function compentence
Gene expression levels in SubtiExpress: comFB
MW, pI 10 kDa, 4.827
Gene length, protein length 294 bp, 98 aa
Immediate neighbours comFC, comFA
Sequences Protein DNA DNA_with_flanks
Genetic context
ComFB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
ComFB expression.png















Categories containing this gene/protein

genetic competence

This gene is a member of the following regulons

ComK regulon

The gene

Basic information

  • Locus tag: BSU35460

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity:


Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Tatyana A Sysoeva, Lukas B Bane, Daphne Y Xiao, Baundauna Bose, Scott S Chilton, Rachelle Gaudet, Briana M Burton
Structural characterization of the late competence protein ComFB from Bacillus subtilis.
Biosci Rep: 2015, 35(2);
[PubMed:25423369] [WorldCat.org] [DOI] (I e)

Miriam Kaufenstein, Martin van der Laan, Peter L Graumann
The three-layered DNA uptake machinery at the cell pole in competent Bacillus subtilis cells is a stable complex.
J Bacteriol: 2011, 193(7);1633-42
[PubMed:21278288] [WorldCat.org] [DOI] (I p)

Hanne Jarmer, Randy Berka, Steen Knudsen, Hans H Saxild
Transcriptome analysis documents induced competence of Bacillus subtilis during nitrogen limiting conditions.
FEMS Microbiol Lett: 2002, 206(2);197-200
[PubMed:11814663] [WorldCat.org] [DOI] (P p)

J A Londoño-Vallejo, D Dubnau
comF, a Bacillus subtilis late competence locus, encodes a protein similar to ATP-dependent RNA/DNA helicases.
Mol Microbiol: 1993, 9(1);119-31
[PubMed:8412657] [WorldCat.org] [DOI] (P p)