YpqP

• Description: C-terminal part of the split gene spsM (together with yodU), spore envelope polysaccharide biosynthesis, in B. subtilis 168 the gene is disrupted by the SP-beta prophage
  
  

Gene name	ypqP
Synonyms
Essential	no
Product	unknown
Function	spore envelope polysaccharide biosynthesis
Gene expression levels in SubtiExpress: ypqP
MW, pI	- , -
Gene length, protein length	606 bp, SpsM: 341 aa
Immediate neighbours	sprA, msrB
Gene sequence (+200bp)	Protein sequence
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

membrane proteins, sporulation proteins

The gene

Basic information

• Locus tag: BSU21670

Database entries

• BsubCyc: BSU21670

• DBTBS entry: [1]

• SubtiList entry: [2]

Additional information

• rearrangement (deletion of the SP-beta prophage and generation of the spsM gene) occurs during sporulation and in response to DNA damage to allow production of spore polysaccharide PubMed

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s): EpsC (for SpsM)

Extended information on the protein

• Kinetic information:

• Domains: SpsM: Polysacc_synt_2 domain (Pfam accession number, PF02719) in the 18–296-aa region PubMed

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane (according to Swiss-Prot)

Database entries

• BsubCyc: BSU21670

• Structure:

• UniProt: P54183

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ypqP (accoriding to DBTBS)

• Expression browser: ypqP PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Pilar Sanchez-Vizuete, Dominique Le Coq, Arnaud Bridier, Jean-Marie Herry, Stéphane Aymerich, Romain Briandet
Identification of ypqP as a New Bacillus subtilis biofilm determinant that mediates the protection of Staphylococcus aureus against antimicrobial agents in mixed-species communities.
Appl Environ Microbiol: 2015, 81(1);109-18
[PubMed:25326298] [WorldCat.org] [DOI] (I p)

Kimihiro Abe, Yuta Kawano, Keito Iwamoto, Kenji Arai, Yuki Maruyama, Patrick Eichenberger, Tsutomu Sato
Developmentally-regulated excision of the SPβ prophage reconstitutes a gene required for spore envelope maturation in Bacillus subtilis.
PLoS Genet: 2014, 10(10);e1004636
[PubMed:25299644] [WorldCat.org] [DOI] (I e)