AppA/1

• Description: oligopeptide ABC transporter, inactive pseudogene in strain 168
  
  

Gene name	appA/1
Synonyms
Essential	no
Product	oligopeptide ABC transporter
Function	unknown
Gene expression levels in SubtiExpress: appA/1
Interactions involving this protein in SubtInteract: AppA
Metabolic function and regulation of this protein in SubtiPathways: appA/1
MW, pI	-, -
Gene length, protein length	462 bp, -
Immediate neighbours	appF, appA/2
Gene sequence (+200bp)	Protein sequence
Genetic context File:AppA/1 context.gif
Expression at a glance   PubMed 500px

Categories containing this gene/protein

ABC transporters, membrane proteins, pseudogenes

This gene is a member of the following regulons

CodY regulon, ScoC regulon

The gene

Basic information

• Locus tag: BSU11381

Database entries

• BsubCyc: BSU11381

• DBTBS entry: no entry

• SubtiList entry: no entry

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • (AppD-AppF)-(AppB-AppC)-AppA PubMed

• Localization: attached to the cell membrane (via AppB-AppC) PubMed

Database entries

• BsubCyc: BSU11381

• Structure:

• Swiss prot entry:

• KEGG entry: [1]

• E.C. number:

Expression and regulation

• Operon: appD-appF-appA-appB-appC PubMed

• Expression browser: appA/1 PubMed

• Sigma factor:

• Regulation:
  • repressed during exponential growth (ScoC) PubMed
  • repressed during growth in the presence of branched chain amino acids (CodY) PubMed

• Regulatory mechanism:
  • ScoC: transcription repression PubMed
  • CodY: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Virginie Molle, Yoshiko Nakaura, Robert P Shivers, Hirotake Yamaguchi, Richard Losick, Yasutaro Fujita, Abraham L Sonenshein
Additional targets of the Bacillus subtilis global regulator CodY identified by chromatin immunoprecipitation and genome-wide transcript analysis.
J Bacteriol: 2003, 185(6);1911-22
[PubMed:12618455] [WorldCat.org] [DOI] (P p)

A Koide, M Perego, J A Hoch
ScoC regulates peptide transport and sporulation initiation in Bacillus subtilis.
J Bacteriol: 1999, 181(13);4114-7
[PubMed:10383984] [WorldCat.org] [DOI] (P p)

Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453] [WorldCat.org] [DOI] (P p)

A Koide, J A Hoch
Identification of a second oligopeptide transport system in Bacillus subtilis and determination of its role in sporulation.
Mol Microbiol: 1994, 13(3);417-26
[PubMed:7997159] [WorldCat.org] [DOI] (P p)

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