Difference between revisions of "ComEA"
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= [[Categories]] containing this gene/protein = | = [[Categories]] containing this gene/protein = | ||
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=== Additional information=== | === Additional information=== | ||
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=The protein= | =The protein= | ||
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* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' | + | * '''[[Domains]]:''' |
| + | ** extracellular DNA-binding domain | ||
* '''Modification:''' | * '''Modification:''' | ||
| − | * ''' | + | * '''[[Cofactors]]:''' |
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=comEA_2640513_2641130_-1 comEA] {{PubMed|22383849}} | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=comEA_2640513_2641130_-1 comEA] {{PubMed|22383849}} | ||
| − | * '''Sigma factor:''' [[SigA]] {{PubMed|7968523}} | + | * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|7968523}} |
* '''Regulation:''' | * '''Regulation:''' | ||
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<pubmed> 15083159 </pubmed> | <pubmed> 15083159 </pubmed> | ||
==Original publications== | ==Original publications== | ||
| − | + | <pubmed>9987128,11814663,7768800,16751195,7968523,17630974, 21278288,19028902, 21707789 22398145</pubmed> | |
| − | <pubmed>9987128,11814663,7768800,16751195,7968523,17630974, 21278288,19028902, 21707789</pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 11:19, 16 March 2014
- Description: membrane DNA receptor, plays an important role in the transfer of transforming DNA into the DNA channel and in controlling the rate of DNA uptake
| Gene name | comEA |
| Synonyms | comD |
| Essential | no |
| Product | membrane DNA receptor |
| Function | genetic competence |
| Gene expression levels in SubtiExpress: comEA | |
| Interactions involving this protein in SubtInteract: ComEA | |
| Metabolic function and regulation of this protein in SubtiPathways: comEA | |
| MW, pI | 21 kDa, 4.824 |
| Gene length, protein length | 615 bp, 205 aa |
| Immediate neighbours | comEB, comER |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
genetic competence, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU25590
Phenotypes of a mutant
- strongly reduced transformation rate PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- extracellular DNA-binding domain
- Modification:
- Effectors of protein activity:
- Localization:
- cell membrane, no distinct position PubMed
Database entries
- Structure: 2DUY (from Thermus thermophilus hb8, 37% identity, 60% similarity)
- UniProt: P39694
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Inês Chen, David Dubnau
DNA uptake during bacterial transformation.
Nat Rev Microbiol: 2004, 2(3);241-9
[PubMed:15083159]
[WorldCat.org]
[DOI]
(P p)
Original publications
