LipC

• Description: spore coat protein, phospholipase implicated in spore germination
  
  

Gene name	lipC
Synonyms	ycsK
Essential	no
Product	spore coat phospholipase B
Function	spore germination
Gene expression levels in SubtiExpress: lipC
Function and regulation of this protein in SubtiPathways: Phosphorelay
MW, pI	23 kDa, 5.839
Gene length, protein length	639 bp, 213 aa
Immediate neighbours	kipR, yczI
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

utilization of lipids, sporulation proteins, germination

This gene is a member of the following regulons

KipR regulon, SigK regulon, TnrA regulon, GerE regulon

The gene

Basic information

• Locus tag: BSU04110

Phenotypes of a mutant

• defective in L-alanine-stimulated germination PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: cleaves the fatty acids at the sn-1 and sn-2 positions of phospholipids PubMed

• Protein family: 'GDSL' lipolytic enzyme family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:

• Interactions:

• Localization:
  • spore coat (basement), localization depends on SpoIVA PubMed

Database entries

• Structure:

• UniProt: P42969

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • ycsF-ycsG-ycsI-kipI-kipA-kipR-lipC PubMed
  • lipC (according to DBTBS)

• Expression browser: lipC PubMed

• Sigma factor:
  • lipC: SigK PubMed

• Regulation:
  • lipC: expressed four hours after onset of sporulation (GerE) PubMed

• Regulatory mechanism:
  • ycsF: KipR: transcription repression PubMed
  • ycsF: TnrA: transcription activation PubMed
  • GerE: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: