Difference between revisions of "BrxA"

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|style="background:#ABCDEF;" align="center"|'''Function''' || de-bacillithiolation of S-bacillithiolated [[OhrR]] and [[MetE]]
 
|style="background:#ABCDEF;" align="center"|'''Function''' || de-bacillithiolation of S-bacillithiolated [[OhrR]] and [[MetE]]
 
|-
 
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU21860 yphP]
+
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU21860 brxA]
 +
|-
 +
|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=BrxA BrxA]
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 15 kDa, 4.619   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 15 kDa, 4.619   
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* '''Catalyzed reaction/ biological activity:'''  
 
* '''Catalyzed reaction/ biological activity:'''  
 +
** de-bacillithiolation of S-bacillithiolated [[OhrR]] and [[MetE]] {{PubMed|24313874}}
  
 
* '''Protein family:''' scpA family (according to Swiss-Prot)
 
* '''Protein family:''' scpA family (according to Swiss-Prot)
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* '''[[SubtInteract|Interactions]]:'''
 
* '''[[SubtInteract|Interactions]]:'''
 +
** [[BrxA]]-[[MetE]] {{PubMed|24313874}}
 +
** [[BrxA]]-[[OhrR]] {{PubMed|24313874}}
  
 
* '''[[Localization]]:'''
 
* '''[[Localization]]:'''
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* '''Operon:''' ''brxA'' (according to [http://dbtbs.hgc.jp/COG/prom/yphP.html DBTBS])
 
* '''Operon:''' ''brxA'' (according to [http://dbtbs.hgc.jp/COG/prom/yphP.html DBTBS])
  
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yphP_2300221_2300655_-1 yphP] {{PubMed|22383849}}
+
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yphP_2300221_2300655_-1 brxA] {{PubMed|22383849}}
  
 
* '''[[Sigma factor]]:'''  
 
* '''[[Sigma factor]]:'''  

Revision as of 19:17, 13 December 2013

  • Description: bacilliredoxin

Gene name brxA
Synonyms yphP
Essential no
Product bacilliredoxin
Function de-bacillithiolation of S-bacillithiolated OhrR and MetE
Gene expression levels in SubtiExpress: brxA
Interactions involving this protein in SubtInteract: BrxA
MW, pI 15 kDa, 4.619
Gene length, protein length 432 bp, 144 aa
Immediate neighbours ypiP, ilvD
Sequences Protein DNA DNA_with_flanks
Genetic context
YphP context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YphP expression.png















Categories containing this gene/protein

resistance against oxidative and electrophile stress

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU21860

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: scpA family (according to Swiss-Prot)
  • Paralogous protein(s): BrxB

Extended information on the protein

  • Kinetic information:
  • Modification:
    • S-bacillithiolation upon hypochlorite stress on Cys-53 PubMed
  • Effectors of protein activity:

Database entries

  • KEGG entry: [4]
  • E.C. number:

Additional information

Expression and regulation

  • Operon: brxA (according to DBTBS)
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

YpdA, BrxA, BrxB and YtxJ co-occur in those species predicted to synthesize bacillithiol.

References