Difference between revisions of "FadR"
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| − | * '''Description:''' transcriptional repressor (TetR family), regulation of fatty acid degradation <br/><br/> | + | * '''Description:''' transcriptional repressor ([[TetR family]]), regulation of fatty acid degradation <br/><br/> |
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= [[Categories]] containing this gene/protein = | = [[Categories]] containing this gene/protein = | ||
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* '''Catalyzed reaction/ biological activity:''' | * '''Catalyzed reaction/ biological activity:''' | ||
| − | * '''Protein family:''' | + | * '''Protein family:''' [[TetR family]] |
* '''Paralogous protein(s):''' | * '''Paralogous protein(s):''' | ||
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=fadR_2917957_2918541_-1 fadR] {{PubMed|22383849}} | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=fadR_2917957_2918541_-1 fadR] {{PubMed|22383849}} | ||
| − | * '''Sigma factor:''' | + | * '''[[Sigma factor]]:''' |
** ''[[lcfA]]'': [[SigA]] {{PubMed|21398533}} | ** ''[[lcfA]]'': [[SigA]] {{PubMed|21398533}} | ||
** ''[[fadR]]'': [[SigA]] {{PubMed|17189250}} | ** ''[[fadR]]'': [[SigA]] {{PubMed|17189250}} | ||
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=References= | =References= | ||
==Reviews== | ==Reviews== | ||
| − | <pubmed>17919287,</pubmed> | + | <pubmed>17919287, 24006471 </pubmed> |
==Original publications== | ==Original publications== | ||
| − | + | <pubmed>17189250,21398533</pubmed> | |
| − | <pubmed>17189250,</pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 16:30, 6 September 2013
- Description: transcriptional repressor (TetR family), regulation of fatty acid degradation
| Gene name | fadR |
| Synonyms | ysiA |
| Essential | no |
| Product | transcriptional repressor |
| Function | regulation of fatty acid degradation |
| Gene expression levels in SubtiExpress: fadR | |
| Metabolic function and regulation of this protein in SubtiPathways: Fatty acid degradation | |
| MW, pI | 21 kDa, 6.118 |
| Gene length, protein length | 582 bp, 194 aa |
| Immediate neighbours | fadB, lcfA |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
utilization of lipids, transcription factors and their control
This gene is a member of the following regulons
The FadR regulon
The gene
Basic information
- Locus tag: BSU28550
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: TetR family
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity: long chain fatty acids act as inducers that release FadR from its operator sites
Database entries
- Structure:
- UniProt: P94548
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- induced by long-chain fatty acids (FadR) PubMed
- subject to carbon catabolite repression (CcpA-HPr(Ser-P) PubMed
- Regulatory mechanism:
- FadR: transcription repression PubMed
- CcpA-HPr(Ser-P): transcription repression PubMed
- Additional information:
Biological materials
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Original publications
Shigeo Tojo, Takenori Satomura, Hiroshi Matsuoka, Kazutake Hirooka, Yasutaro Fujita
Catabolite repression of the Bacillus subtilis FadR regulon, which is involved in fatty acid catabolism.
J Bacteriol: 2011, 193(10);2388-95
[PubMed:21398533]
[WorldCat.org]
[DOI]
(I p)
Hiroshi Matsuoka, Kazutake Hirooka, Yasutaro Fujita
Organization and function of the YsiA regulon of Bacillus subtilis involved in fatty acid degradation.
J Biol Chem: 2007, 282(8);5180-94
[PubMed:17189250]
[WorldCat.org]
[DOI]
(P p)
