Difference between revisions of "SpoIVA"

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Revision as of 13:46, 16 May 2013

  • Description: ATPase, spore coat morphogenetic protein, anchors the spore coat to the spore surface via SpoVM

Gene name spoIVA
Synonyms spoVP
Essential no
Product ATPase, basement layer protein for spore coat assembly
Function spore cortex formation and coat assembly
Gene expression levels in SubtiExpress: spoIVA
Interactions involving this protein in SubtInteract: SpoIVA
MW, pI 55 kDa, 4.546
Gene length, protein length 1476 bp, 492 aa
Immediate neighbours hbs, yphF
Sequences Protein DNA DNA_with_flanks
Genetic context
SpoIVA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
SpoIVA expression.png















Categories containing this gene/protein

sporulation proteins

This gene is a member of the following regulons

SigE regulon, SpoIIID regulon

The gene

Basic information

  • Locus tag: BSU22800

Phenotypes of a mutant

  • the spore coat does not localize to the spore surface but self-assembles into aggregates in the mother cell cytoplasm PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • uses ATP hydrolysis to drive self-assembly into static filaments PubMed
    • ATP hydrolysis drives polymerization of a nucleotide-free filament PubMed
    • ploymerization depends on a critical threshold concentration of SpoIVA that is only achieved once the protein is recruited to the surface of the developing spore PubMed
  • Protein family:
    • belongs to the TRAFAC class of P-loop GTPases, but has lost the ability to bind GTP PubMed
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed