Difference between revisions of "PpsA"

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Revision as of 13:30, 16 May 2013

  • Description: plipastatin synthetase

Gene name ppsA
Synonyms
Essential no
Product plipastatin synthetase
Function production of the antibacterial compound plipastatin
Gene expression levels in SubtiExpress: ppsA
MW, pI 288 kDa, 5.221
Gene length, protein length 7683 bp, 2561 aa
Immediate neighbours ppsB, dacC
Sequences Protein DNA DNA_with_flanks
Genetic context
PpsA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
PpsA expression.png
























Categories containing this gene/protein

miscellaneous metabolic pathways, biosynthesis of antibacterial compounds

This gene is a member of the following regulons

AbrB regulon

The gene

Basic information

  • Locus tag: BSU18340

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: ATP-dependent AMP-binding enzyme family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed

K Tsuge, T Ano, M Hirai, Y Nakamura, M Shoda
The genes degQ, pps, and lpa-8 (sfp) are responsible for conversion of Bacillus subtilis 168 to plipastatin production.
Antimicrob Agents Chemother: 1999, 43(9);2183-92
[PubMed:10471562] [WorldCat.org] [DOI] (P p)

Valentina Tosato, Alessandra M Albertini, Michela Zotti, Sabrina Sonda, Carlo V Bruschi
Sequence completion, identification and definition of the fengycin operon in Bacillus subtilis 168.
Microbiology (Reading): 1997, 143 ( Pt 11);3443-3450
[PubMed:9387222] [WorldCat.org] [DOI] (P p)