Difference between revisions of "YhxA"

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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yhzG]]'', ''[[glpP]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yhzG]]'', ''[[glpP]]''
 
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU09260 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU09260 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU09260 Advanced_DNA]
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU09260 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU09260 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU09260 DNA_with_flanks]
 
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Revision as of 09:47, 14 May 2013

  • Description: similar to adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene name yhxA
Synonyms
Essential no
Product unknown
Function unknown
Gene expression levels in SubtiExpress: yhxA
MW, pI 49 kDa, 5.644
Gene length, protein length 1350 bp, 450 aa
Immediate neighbours yhzG, glpP
Sequences Protein DNA DNA_with_flanks
Genetic context
YhxA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YhxA expression.png


























Categories containing this gene/protein

poorly characterized/ putative enzymes

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU09260

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: class-III pyridoxal-phosphate-dependent aminotransferase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

  • subject to Clp-dependent proteolysis upon glucose starvation PubMed

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:
    • half-life of the mRNA: 3.7 min PubMed
    • the mRNA is stabilized in rppH and rnjA mutants PubMed
    • the mRNA is subject to degradation by RNase J1 PubMed
    • subject to Clp-dependent proteolysis upon glucose starvation PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Jamie Richards, Quansheng Liu, Olivier Pellegrini, Helena Celesnik, Shiyi Yao, David H Bechhofer, Ciarán Condon, Joel G Belasco
An RNA pyrophosphohydrolase triggers 5'-exonucleolytic degradation of mRNA in Bacillus subtilis.
Mol Cell: 2011, 43(6);940-9
[PubMed:21925382] [WorldCat.org] [DOI] (I p)

Ulf Gerth, Holger Kock, Ilja Kusters, Stephan Michalik, Robert L Switzer, Michael Hecker
Clp-dependent proteolysis down-regulates central metabolic pathways in glucose-starved Bacillus subtilis.
J Bacteriol: 2008, 190(1);321-31
[PubMed:17981983] [WorldCat.org] [DOI] (I p)

C Holmberg, L Beijer, B Rutberg, L Rutberg
Glycerol catabolism in Bacillus subtilis: nucleotide sequence of the genes encoding glycerol kinase (glpK) and glycerol-3-phosphate dehydrogenase (glpD).
J Gen Microbiol: 1990, 136(12);2367-75
[PubMed:2127799] [WorldCat.org] [DOI] (P p)